Aurelis
Pharmacokinetic simulation cockpit
Tune a compartmental model and watch the drug move. The engine solves the disposition in real time and renders the concentration field as a spatial landscape.
Spatial profile
Concentration - time
Derived parameters
20.8
24
0.67
398
4.85
0.143
35.0
5.00
Reading the model
Clearance (CL)
Volume of plasma cleared of drug per hour. With volume it sets the elimination rate and half-life.
Volume of distribution (V)
Apparent volume relating the amount in the body to plasma concentration. Larger V means lower peak concentration.
Two-compartment model
Adds a peripheral tissue space. Drug distributes out (fast phase) then redistributes back and clears (terminal phase).
First-order absorption
Oral dosing absorbs at rate ka with bioavailable fraction F, producing a rise to Cmax then decline.